A REVIEW OF SODIUM PENTOBARBITAL SOLUBILITY

Observe Closely (one)pentobarbital will lessen the level or effect of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the lessen in fentanyl plasma concentrations, lack of efficacy or, perhaps, improvement of the withdrawal